The interaction of sodium nitroprusside with human endothelial cells and platelets: nitroprusside and prostacyclin synergistically inhibit platelet function.
نویسندگان
چکیده
منابع مشابه
The interaction of sodium nitroprusside with human endothelial cells and platelets: nitroprusside and prostacyclin synergistically inhibit platelet function.
Sodium nitroprusside (NP) is a potent vasodilator that also inhibits platelet aggregation. To test the hypothesis that NP causes both of these effects by altering the balance between prostacyclin (PGI2) produced by endothelial cells and thromboxane A2 (TXA2) produced by platelets, we incubated each of these cell types with NP for 5 minutes and assayed the PGI2 and TXA2 produced. NP at pharmacol...
متن کاملProstacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation.
Prostaglandin I2 (PGI2) and sodium nitroprusside (SNP) induce a rapid decay of the thrombin-promoted increase of [Ca2+]i in aspirin-treated platelets incubated in the absence of external Ca2+. The mechanism of their effect was studied with a new method which utilizes ionomycin to increase [Ca2+]i, followed by bovine serum albumin (BSA) to remove the Ca2+ ionophore. The rapid decay of [Ca2+]i af...
متن کاملDeliberately Lowering Blood Pressure with Sodium Nitroprusside
The goal of hyptensive anesthesia is the safe reduction of intraoperative blood loss, thus reducing transfusion risks. Previous hypotensive technics had a narrow margin of safety in that cardiac output was usually reduced in proportion to the degree of induced hypotension. This is in contrast to the results of our study, in which Sodium Nitroprusside was used as the sole hypotensive agent. Ni...
متن کاملSodium nitroprusside: theory and practice.
Sodium nitroprusside, by a peripheral vasodilator action, is a powerful hypotensive drug. In contrast to established agents, its hypotensive action is accompanied by an unchanged or augmented cardiac output. Intravenous administration of sodium nitroprusside rapidly produces a profound and controllable hypotension. Normotension is swiftly restored by ceasing to infuse the agent, and antidotes a...
متن کاملSodium Nitroprusside Injection
Except when used briefly or at low (< 2 mcg/kg/min) infus ion rates , sodium nitropruss ide gives rise to important quantities of cyanide ion, which can reach toxic, potentially lethal levels (see WARNINGS). The usual dose rate is 0.5 to 10 mcg/kg/min, but infus ion at the maximum dose rate should never las t more than 10 minutes . If blood pressure has not been adequately controlled after 10 m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 1982
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.66.6.1299